We are Developing Innovative Drugs for Metabolic Diseases

Poxel is a clinical stage biopharmaceutical company developing innovative treatments for chronic serious diseases with metabolic pathophysiology, including non-alcoholic steatohepatitis (NASH) and rare disorders. Poxel has clinical and earlier-stage programs from its adenosine monophosphate-activated protein kinase (AMPK) activator and deuterium-modified thiazolidinedione (dTZD) platforms targeting chronic and rare metabolic diseases. Poxel’s first-in-class lead product, TWYMEEG® (Imeglimin), that targets mitochondrial dysfunction, has been approved for the treatment of type 2 diabetes in Japan.

Mission & Vision

Mission and Vision

Our Strategy

Our goals are to develop and commercialize innovative therapies for the treatment of serious chronic and rare diseases with underlying metabolic pathophysiology.  To achieve these goals, we are pursuing the following strategy:

  • Develop and commercialize our rare metabolic diseases portfolio by building upon our proven capabilities and existing platforms and by acquiring additional drug candidates and technologies
  • Advance one of our programs in NASH and one in ALD into later stage development
  • Continue to maximize value of Imeglimin (TWYMEEG) by supporting our partner, Sumitomo Pharma, and advance Imeglimin for the treatment of type 2 diabetes to commercialization (outside Japan), including partnering activities
  • Maximize the commercial potential of our wholly owned assets and opportunistically enter into strategic collaborations

New Chapter to Drive Shareholder Value: Focus on Rare Metabolic Diseases and NASH

Scientific Focus
Targeting Cellular Energy Metabolism

We believe that targeting cellular energy regulation pathways is of critical importance as imbalances are at the root of metabolic diseases. Each of our clinical programs address significant targets in the energy metabolism pathways:

  • PXL065 selectively targets non-genomic (non-PPAR) pathways modulated by TZDs including inhibition of the mitochondrial pyruvate carrier (MPC), a fuel gatekeeper
  • PXL770 activates the adenosine monophosphate-activated protein kinase (AMPK), an important energy sensor
  • Imeglimin targets mitochondrial dysfunction, mitochondria being the power stations of the cell

Graph of Poxel Platforms Targeting Key Nodes that Regulate Cellular Energy Homeostasis

Leading Expertise in Metabolic Diseases Backed by Years of Experience

We were founded in 2009 by focused group of scientific and drug development leaders from Merck Serono through a spin-off of its metabolic-focused business, as part of a strategic realignment following the acquisition of Serono by Merck. Our scientific expertise is based on the understanding of key mechanisms involved in metabolic pathways and diseases and the innovation needed to make an impact on the current standard of care.

Poxel’s first-in-class lead product, TWYMEEG (Imeglimin), that targets mitochondrial dysfunction, was approved for the treatment of type 2 diabetes in Japan in June 2021 and is now commercialized. With this approval, Poxel is entitled to receive milestones, sales-based payments and royalties from Sumitomo Pharma. Poxel has a strategic partnership with Sumitomo Pharma for Imeglimin in Japan, China, South Korea, Taiwan and nine other Southeast Asian countries.

Our management team and Board of Directors have extensive pharmaceutical industry experience spanning the spectrum of drug research and development to commercialization, patient access and life-cycle management. We continue to strengthen our management team, which now combines extensive experience in metabolic pathways and indications, rare diseases, clinical research and development, and global regulatory affairs, with the business and financial expertise needed for drug development and corporate partnerships.

We are continuing to build a world-class metabolic research and development organization with offices in Lyon, France, Boston, Massachusetts and Tokyo, Japan.

Management Team

Board of Directors

Scientific Advisory Board